龙源期刊网 https://www.doczj.com/doc/cd768320.html,
血管内皮功能损伤与氧化应激在急性冠脉综合征合并糖尿病患者血浆中相关性研究
作者：李雅赵学伟陈彦霞高淑贤李雪松
来源：《中国医学创新》2015年第32期
【摘要】目的：研究血管内皮功能损伤与氧化应激在急性冠脉综合征合并糖尿病患者血
浆中相关性。方法：选取2012年8月-2014年12月于本院心内科住院的急性冠脉综合征合并糖尿病患者200例作为研究对象，将其分为不稳定型心绞痛组（UAP组）和急性心肌梗死组（AMI组），同时选取本院120例健康体检者作为对照组。测定并比较各组血管功能及氧化应激相关指标。结果：AMI组及UAP组NO、SOD、GSH-Px水平均低于对照组，而ET-1水平高于对照组；AMI组ET-1水平均高于UAP组，GSH-Px及SOD水平低于UAP组，比较差异均有统计学意义（P
【关键词】血管内皮；氧化应激；急性冠脉综合征；糖尿病
【Abstract】 Objective：To study the correlation between the vascular endothelial functional damage and oxidative stress in plasma of patients with acute coronary syndrome combined with diabetes.Method：A total of 200 patients with vascular endothelial functional damage and oxidative stress in our hospital from August 2012 to December 2014 were selected as the research objects.They were divided into the unstable angina pectoris group（group UAP） and the acute myocardial infarction group（group AMI）.120 healthy persons who received health examination in our hospital were selected as the control group at the same time.The indexes of vascular function and oxidative stress in the three groups were tested and compared.Result：The levels of NO，SOD and GSH-Px in group UAP and group AMI were lower than those in the control group，while the level of ET-1 was higher than that in the control group.The level of ET-1 in group AMI was higher than that in group UAP，while the levels of GSH-Px and SOD were lower than those in group UAP.The differences above were all statistically significant（P
【Key words】 Vascular endothelia； Oxidative stress； Acute coronary syndrome； Diabetes
First-author’s address：The Affiliated Hospital of Hebei University，Baoding 071000，China
doi：10.3969/j.issn.1674-4985.2015.32.018
糖尿病为冠心病的等位症，高糖会造成体内发生血脂代谢异常，容易发生高脂血症、高胆固醇血症等疾病，糖尿病患者本身都存在炎性反应，炎性因子导致血管壁损伤，引起细胞破坏、胆固醇沉积，导致动脉粥样硬化[1]。目前大量研究表明，氧化应激参与了动脉硬化的发
生与发展过程。氧化应激是指机体组织或细胞内氧自由基生成增加和/或清除能力降低，导致氧自由基及其相关代谢产物的过度积聚而引起氧化损伤的过程。氧化应激一方面直接对血管壁