Biomed Environ Sci, 2019; 32(5): 383-388383
Letter to the Editor
s
Serum Glypican 4 Levels Are Associated with Metabolic
Syndrome in a Han Population from Guizhou Province, China
d icaland
Environmental Sciences
NING Dong Ping* 1'2'3, XU Ke1'4, ZHU Hui Juan1, SHAN Guang Liang5, WANG Ding Ming6,
PING Bo7, YU Yang Wen6, PAN Hui1’#，and GONG Feng Ying1，#
Metabolic s y n d r o m e (MetS) i s the presence of a battery of cardiovascular risk factors including abdominal obesity, hypertension, dyslipidemia, and
disturbed carbohydrate metabolism111. M e t S affects 20% of adults in the Western world and 33% of adults in China121 and has b e c o m e a serious public health
problem
worldwide.
However, the m e c h a n i s m
underlying
the
occurrence
and
progression of M e t S i s s t i l l largely unclear. I t i s n o w well established that excess fat deposition leads to abdominal obesity, which plays a vital role in the underlying mechanism. Adipose tissue can function as an endocrine organ that secretes various adipokines.
The
dysregulated
expression
of
adipokines caused by excess adiposity and adipocyte dysfunction, has been linked to the pathogenesis of M e t S 13]. S o m e serum adipokines such as leptin, adiponectin, interleukin 6 (IL-6), and t u m o u r necrosis factor-a (TNF-a), might be potential markers for M e t S development.
Glypican 4 (Gpc4) w a s firstly discovered by W a t a n a b a et a l . in the brains and kidneys of mice in 1995[4]. Ussar et a l . have confirmed G p c 4 as a newly identified adipokine that i s secreted by adipose tissue in 2012【51. G p c 4 belongs to the family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans. G p c 4 can interact with the insulin receptor and enhance insulin signaling, which then promotes adipocyte differentiation15,61. I t has been reported that high serum G p c 4 levels are related with high homeostasis m o d e l assessment of insulin
resistance (HOMA-IR) scores and high fasting insulin levels15,61. Y oo et a l . found that s e r u m G p c 4 levels w e r e significantly related with cardiovascular risk
factors including insulin resistance (IR) and body fat distribution in Asian w o m e n [7]. O u r t e a m previously discovered that G p c 4 w a s associated with obesity and
IR.
S e r u m
G p c 4
concentrations
were
significantly elevated in obese subjects with IR and positively related with body ma s s index (BMI)' systolic
blood
pressure
(SBP),
alanine
aminotransferase (ALT), aspartate aminotransferase (AST), fasting insulin (FINS), and H O M A -I R score[8]. All these findings have demonstrated that G p c 4 i s a novel adipokine that m a y play a crucial role i n metabolic disorders. Therefore, i t i s reasonable for us to w o n d e r whether G p c 4 has any relation with MetS.
Thus, the aim of our present study w a s to investigate the changes of serum G p c 4 levels and the correlations of G p c 4 levels with M e t S c o m p o n e n t s in a H a n population with different metabolic statuses from Guizhou Province in China. In addition, the association b e t ween circulating G p c 4 concentrations and the risk of M e t S w a s also assessed in our study.T he included participants w e r e recruited from the National Physical and Health Survey Project of the 12t h Five-Year Plan of Science and Technology Support, which w a s a cross-sectional survey of Han Chinese adults in Guizhou Province in 2012. In total, 312 subjects (male 132, female 180) we r e selected according to age and gender. All the subjects were
doi: 10.3967/bes2019.052
This study was funded by the National Science and Technology Pillar Program during the Twelfth Five-Year Plan Period sponsored by the Ministry of Science and Technology of China [No. 2012BAI37B02]; CAMS Innovation Fund for Medical Science [No. 2016-12M-l-008]; the National Natural Science Foundation of China [No. 81673184, 81370898]; Beijing Natural Science Foundation [No. 7082079, 7182130]; National Key Program of Clinical Science [No. WBYZ2011-873].
1. Key Laboratory of Endocrinology of National Health Commission, Dept, of Endocrinology, Peking Union Medical College Hospital, Translation Medicine Centre, CAMS & PUMC, Beijing 100730, China;
2. Graduate School, Hebei North University, Zhangjiakou 075000, Hebei, China;
3. Linfen Central Hospital, Linfen 041000, Shanxi, China;
4. Dept, of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Zhejiang Provincial First Hospital of Wenzhou,Wenzhou 325000, Zhejiang, China;
5. Dept, of Epidemiology and Health Statistics, Institute of Basic Medical Sciences, CAMS & PUMC; Beijing 100005, China;
6. Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, Guizhou,China;
7. Longli Center for Disease Control and Prevention, Longli
551200, Guizhou, China