Product Name:
Stavudine sodium CAS No.:
134624-73-0Cat. No.:
HY-B0116A Product Data Sheet
MWt:
246.20Formula:
C10H11N2NaO4Purity :>98%
Solubility:
DMSO 45 mg/mL ; Water 45y Mechanisms:Biological Activity:
Stavudine sodium is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity
Pathways:Anti-infection; Target:HIV
Pathways:Anti-infection; Target:NRTIs g mg/mL
Stavudine sodium is a nucleoside analog that inhibits reverse transcriptase and has in vitro activity
against HIV.
Target: HIV RT; NRTIs Stavudine sodium is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine sodium is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine sodium triphosphate inhibits the HIV reverse
transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination
of DNA synthesis by incorporating into it [1]. Mice were treated for 2 weeks with stavudine d4T (500 mg/kg/day), L-carnitine (200 mg/kg/day) or References:
[1]. Lea AP, et al. Stavudine: a review of its pharmacodynamic and pharmacokinetic properties and
clinical potential in HIV infection. Drugs. 1996 May;51(5):846-64.[2]. Igoudjil A, et al. High doses of stavudine induce fat wasting and mild liver damage without (g g y),(g g y)both drugs concomitantly. Body fatness was assessed by dual energy X-ray absorptiometry, and investigations were performed in plasma, liver, muscle and WAT. D4T reduced the gain of body adiposity, WAT leptin,...
impairing mitochondrial respiration in mice. Antivir Ther. 2007;12(3):389-400.Caution: Not fully tested. For research purposes only
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